Innate Immunity & Critical Illness
Clinical Lead:
Research Lead:
Principal Investigators:
The Innate Immunity research theme within the Cardiff Institute of Infection & Immunity comprises internationally known experts in innate immunity covering all areas of the field – from Toll-like receptors and other innate immune sensors, to studying the molecular and cellular interactions between different innate players, to understanding the clinical implications of a disregulated innate immune response in disease.
The grouping brings together clinicians and basic scientists and provides the perfect environment for translational research at the interface of clinical and basic research.
Selected recent publications
- IL-21 enhances the potential of human γδ T cells to provide B-cell help.
Bansal RR, Mackay CR, Moser B, Eberl M, Eur J Immunol, Volume 42, 1 (January 2012) pp.110-119 - Complement takes its Toll: an inflammatory crosstalk between Toll-like receptors and the receptors for the complement anaphylatoxin C5a.
Holst B, Raby AC, Hall JE, Labéta MO, Anaesthesia, Volume 67, 1 (January 2012) pp.60-64 - Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors.
Colmont CS, Raby AC, Dioszeghy V, Lebouder E, Foster TL, Jones SA, Labéta MO, Fielding CA, Topley N, Nephrol Dial Transplant, Volume 26, 12 (December 2011) pp.4079-4090 - Failure to detect production of IL-10 by activated human neutrophils
Davey MS, Tamassia N, Rossato M, Bazzoni F, Calzetti F, Bruderek K, Sironi M, Zimmer L, Bottazzi B, Mantovani A, Brandau S, Moser B, Eberl M, Cassatella MA, Nature Immunol, Volume 12, 11 (November 2011) pp.1017-1018 - Suppression of apoptosis inhibitor c-FLIP selectively sensitizes breast cancer stem cells to the anti-cancer agent, TRAIL
Piggot L, Omidvar N, Martí Pérez S, Eberl M, Clarkson RWE, Breast Cancer Res, Volume 13, 5 (September 2011) p. R88 - TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2.
Raby AC, Holst B, Davies J, Colmont C, Laumonnier Y, Coles B, Shah S, Hall J, Topley N, Köhl J, Morgan BP, Labéta MO, Eur J Immunol, Volume 41, 9 (September 2011) pp.2741-2752 - Evaluation of a pulse oximeter sensor tester.
Dugani S, Hodzovic I, Sindhakar S, Nadra A, Dunstan C, Wilkes AR, Mecklenburgh J, J Clin Monit Comput, Volume 25, 3 (June 2011) pp.163-170 - Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection.
Davey MS, Lin CY, Roberts GW, Heuston S, Brown AC, Chess JA, Toleman MA, Gahan CG, Hill C, Parish T, Williams JD, Davies SJ, Johnson DW, Topley N, Moser B, Eberl M, Plos Pathog, Volume 7, 5 (May 2011) pp.e1002040-e1002040