Innate Immunity & Critical Illness
Clinical Lead:
Research Lead:
Principal Investigators:
The Innate Immunity research theme within the Cardiff Institute of Infection & Immunity comprises internationally known experts in innate immunity covering all areas of the field – from Toll-like receptors and other innate immune sensors, to studying the molecular and cellular interactions between different innate players, to understanding the clinical implications of a disregulated innate immune response in disease.
The grouping brings together clinicians and basic scientists and provides the perfect environment for translational research at the interface of clinical and basic research.
Selected recent publications
- Targeting the TLR Co-Receptor CD14 with TLR2-Derived Peptides Modulates Immune Responses to Pathogens.
Raby AC, Holst B, Le Bouder E, Diaz C, Ferran E, Conraux L, Guillemot JC, Coles B, Kift-Morgan A, Colmont CS, Szakmany T, Ferrara P, Hall JE, Topley N, Labéta MO, Sci Transl Med, Volume 5, 185 (May 2013) p. 185ra64 - Monocytes and γδ T cells control the acute-phase response to intravenous zoledronate: insights from a phase IV safety trial.
Welton JL, Morgan MP, Martí S, Stone MD, Moser B, Sewell AK, Turton J, Eberl M, J Bone Miner Res, Volume 28, 3 (March 2013) pp.464-471 - Clinical Significance and Management of Sentinel
Node Micrometastasis in Invasive Breast Cancer
McWilliams B, Jafferbhoy S, Clinical Breast Cancer, Volume 12, 5 (October 2012) pp.308-12 - IL-21 enhances the potential of human γδ T cells to provide B-cell help.
Bansal RR, Mackay CR, Moser B, Eberl M, Eur J Immunol, Volume 42, 1 (January 2012) pp.110-119 - Complement takes its Toll: an inflammatory crosstalk between Toll-like receptors and the receptors for the complement anaphylatoxin C5a.
Holst B, Raby AC, Hall JE, Labéta MO, Anaesthesia, Volume 67, 1 (January 2012) pp.60-64 - Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors.
Colmont CS, Raby AC, Dioszeghy V, Lebouder E, Foster TL, Jones SA, Labéta MO, Fielding CA, Topley N, Nephrol Dial Transplant, Volume 26, 12 (December 2011) pp.4079-4090 - Failure to detect production of IL-10 by activated human neutrophils.
Davey MS, Tamassia N, Rossato M, Bazzoni F, Calzetti F, Bruderek K, Sironi M, Zimmer L, Bottazzi B, Mantovani A, Brandau S, Moser B, Eberl M, Cassatella MA, Nat Immunol, Volume 12, 11 (November 2011) pp.1017-1018 - TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2.
Raby AC, Holst B, Davies J, Colmont C, Laumonnier Y, Coles B, Shah S, Hall J, Topley N, Köhl J, Morgan BP, Labéta MO, Eur J Immunol, Volume 41, 9 (September 2011) pp.2741-2752