Characterisation of novel esterified oxidised phospholipids in human platelets
Cardiff Institute of Infection & Immunity
A three-year project examining the structures of phospholipids and their biological actions in regulating platelet function. Studies will be done on both isolated platelets from healthy volunteers, and via human supplementation studies
Fish oil has long been known to possess anti-platelet effects, leading to suggestions that it may have protective actions in cardiovascular disease and thrombosis. We have found that human platelets generate a series of novel phospholipids that contain oxidised docosahexanoic acid (DHA, the major fatty acid in fish oil). This project will determine the structures of these molecules and their biological actions in regulating platelet function. Studies will be done on both isolated platelets from healthy volunteers, and via human supplementation studies
- Please contact
- Miss Rosemary Granger
- Closing date for applications
- 1st September 2009