The i3-IRG undertakes basic, translational and clinical research in order to further our understanding of the immune system for better diagnosis and therapy of infection, inflammation, autoimmunity and cancer.
The immune system in action: a T cell on the hunt for antigens.
Studying the immune system
The immune system protects the body against infection and disease, but can also cause disease when it goes awry. Our research aims to develop new vaccines, diagnostics and treatments for diseases such as AIDS, arthritis, flu and cancer.
Through interdisciplinary collaborations across the School, the University and beyond, we focus on research and treatment strategies seeks to link high quality laboratory-based research with translational, cross-disciplinary clinical applications.
Interdisciplinary immunological research
The i3-IRG is a large team of nearly 150 researchers from different fields of expertise. Our research involves collaborations between hospital doctors and laboratory scientists, who share knowledge through regular conferences and workshops.
Our group includes nine professors, and we are currently training 24 PhD students.
Most members of the i3-IRG work in different research institutes across the School of Medicine but we also have members coming from the Schools of Dentistry, Pharmacy and Biosciences at Cardiff University, and from Swansea University.
The Henry Wellcome Building for Biomedical Research (upper left), in which many of the i3-IRG researchers are located; Gregynog Hall in mid-Wales (upper right), one of the venues for the annual retreat of the i3-IRG; and the University Hospital of Wales (below), where many of the translational and clinical projects within the i3-IRG are placed
News
- Death Receptor 3 on the brain
- Nominations for Early Career Representative
- HPV researcher suggests benefits of HPV vaccines for boys
- Knowledge Transfer Partnership Award to Prof Andrew Sewell
- Recognising excellence
- Nobel Laureate appointed as president at Cardiff University
- T cells and diabetes
- Dectin-2 and fungal infection
- i3-IRG student wins prize in Graduate School Event
- Boost to T cell research in Cardiff
Events
- This week
- This month
- Next month & beyond
Selected recent publications
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Age-Dependent Maintenance of Motor Controland Corticostriatal Innervation by Death Receptor 3.
Twohig JP et al, J Neurosci -
Phospholipid-esterified Eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation.
Thomas CP et al, J Biol Chem -
Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38.
Pearce L et al, Haematologica -
Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells.
Hole PS et al, Blood -
Upregulating CD59: a new strategy for protection of neurons from complement-mediated degeneration.
Kolev MV et al, Pharmacogenomics J - More i3-IRG publications