The i3-IRG undertakes basic, translational and clinical research in order to further our understanding of the immune system for better diagnosis and therapy of infection, inflammation, autoimmunity and cancer.
Studying the immune system
The immune system protects the body against infection and disease, but can also cause disease when it goes awry. Our research aims to develop new vaccines, diagnostics and treatments for diseases such as AIDS, arthritis, flu and cancer.
Through interdisciplinary collaborations across the School, the University and beyond, we focus on research and treatment strategies seeks to link high quality laboratory-based research with translational, cross-disciplinary clinical applications.
Interdisciplinary immunological research
The i3-IRG is a large team of nearly 150 researchers from different fields of expertise. Our research involves collaborations between hospital doctors and laboratory scientists, who share knowledge through regular conferences and workshops.
Our group includes nine professors, and we are currently training 24 PhD students.
Most members of the i3-IRG work in different research institutes across the School of Medicine but we also have members coming from the Schools of Biosciences, Dentistry and Pharmacy at Cardiff University, and from Swansea University.
News
- June 2010
- May 2010
Events
- September 2010
- October 2010
- November 2010
Selected recent publications
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In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.
Meraviglia S, Eberl M, Vermijlen D, Todaro M, Buccheri S, Cicero G, La Mendola C, Guggino G, D'Asaro M, Orlando V, Scarpa F, Roberts A, Caccamo N, Stassi G, Dieli F, Hayday AC, Clin Exp Immunol , Volume 161 , 2 (August 2010) pp.290-297 -
Resistance of CD45RA- T cells to apoptosis and functional impairment, and activation of tumor-antigen specific T cells during radiation therapy of prostate cancer.
Tabi Z, Spary LK, Coleman S, Clayton A, Mason MD, Staffurth J, J Immunol , Volume 185 , 2 (July 2010) pp.1330-1339 -
Telomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis.
Lin TT, Letsolo BT, Jones RE, Rowson J, Pratt G, Hewamana S, Fegan C, Pepper C, Baird DM, Blood (June 2010) -
Proteomics analysis of bladder cancer exosomes.
Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A, Mol Cell Proteomics , Volume 9 , 6 (June 2010) pp.1324-1338 -
Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture.
Dargan DJ, Douglas E, Cunningham C, Jamieson F, Stanton RJ, Baluchova K, McSharry BP, Tomasec P, Emery VC, Percivalle E, Sarasini A, Gerna G, Wilkinson GW, Davison AJ, J Gen Virol , Volume 91 , Pt 6 (June 2010) pp.1535-1546 - More i3-IRG publications