The i3-IRG undertakes basic, translational and clinical research in order to further our understanding of the immune system for better diagnosis and therapy of infection, inflammation, autoimmunity and cancer.
Studying the immune system
The immune system protects the body against infection and disease, but can also cause disease when it goes awry. Our research aims to develop new vaccines, diagnostics and treatments for diseases such as AIDS, arthritis, flu and cancer.
Through interdisciplinary collaborations across the School, the University and beyond, we focus on research and treatment strategies seeks to link high quality laboratory-based research with translational, cross-disciplinary clinical applications.
Interdisciplinary immunological research
The i3-IRG is a large team of nearly 150 researchers from different fields of expertise. Our research involves collaborations between hospital doctors and laboratory scientists, who share knowledge through regular conferences and workshops.
Our group includes >15 professors, and we are currently training >24 PhD students.
Most members of the i3-IRG work in different research institutes across the School of Medicine but we also have members coming from the Schools of Biosciences, Dentistry and Pharmacy at Cardiff University, and from Swansea University.
News
- January 2012
- December 2011
- November 2011
Events
- February 2012
- March 2012
- April 2012
- May 2012
Selected recent publications
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Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Bulek AM, Cole DK, Skowera A, Dolton G, Gras S, Madura F, Fuller A, Miles JJ, Gostick E, Price DA, Drijfhout JW, Knight RR, Huang GC, Lissin N, Molloy PE, Wooldridge L, Jakobsen BK, Rossjohn J, Peakman M, Rizkallah PJ, Sewell AK, Nat Immunol (January 2012) -
A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome.
Francis NJ, McNicholas B, Awan A, Waldron M, Reddan D, Sadlier D, Kavanagh D, Strain L, Marchbank KJ, Harris CL, Goodship TH, Blood , Volume 119 , 2 (January 2012) pp.591-601 -
A single autoimmune T cell receptor recognizes more than a million different peptides.
Wooldridge L, Ekeruche-Makinde J, van den Berg HA, Skowera A, Miles JJ, Tan MP, Dolton G, Clement M, Llewellyn-Lacey S, Price DA, Peakman M, Sewell AK, J Biol Chem , Volume 287 , 2 (January 2012) pp.1168-1177 -
IL-21 enhances the potential of human γδ T cells to provide B-cell help.
Bansal RR, Mackay CR, Moser B, Eberl M, Eur J Immunol , Volume 42 , 1 (January 2012) pp.110-119 -
Effect of late preterm birth on longitudinal lung spirometry in school age children and adolescents.
Kotecha SJ, Watkins WJ, Paranjothy S, Dunstan FD, Henderson AJ, Kotecha S, Thorax , Volume 67 , 1 (January 2012) pp.54-61 - More i3-IRG publications