The i3-IRG undertakes basic, translational and clinical research in order to further our understanding of the immune system for better diagnosis and therapy of infection, inflammation, autoimmunity and cancer.
Studying the immune system
The immune system protects the body against infection and disease, but can also cause disease when it goes awry.
Our research aims to develop new vaccines, diagnostics and treatments for diseases such as AIDS, arthritis, flu and cancer.
Through interdisciplinary collaborations across the School, the University and beyond, we focus on research and treatment strategies seeks to link high quality laboratory-based research with translational, cross-disciplinary clinical applications.
The immune system in action: a T cell on the hunt for antigens.
Interdisciplinary immunological research
The i3-IRG is a large team of nearly 150 researchers from different fields of expertise. Our research involves collaborations between hospital doctors and laboratory scientists, who share knowledge through regular conferences and workshops.
Our group includes nine professors, and we are currently training 24 PhD students. Members of the i3-IRG work in different research institutes across the School of Medicine.
Due to the interdisciplinary nature of our research we are also open to people from other institutions and are proud to have members coming from the Schools of Dentistry, Pharmacy and Biosciences at Cardiff University, and the Institute of Life Science at Swansea University.
The Henry Wellcome Building for Biomedical Research (upper left), in which many of the i3-IRG researchers are located; Gregynog Hall in mid-Wales (upper right), one of the venues for the annual retreat of the i3-IRG; and the University Hospital of Wales (below), where many of the translational and clinical projects within the i3-IRG are placed.
i3-IRG related information in brief
News
- Nominations for Early Career Representative
- HPV researcher suggests benefits of HPV vaccines for boys
- Knowledge Transfer Partnership Award to Prof Andrew Sewell
- Recognising excellence
- Nobel Laureate appointed as president at Cardiff University
- T cells and diabetes
- Dectin-2 and fungal infection
- i3-IRG student wins prize in Graduate School Event
Events
- This week
- This month
Selected recent publications
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Phospholipid-esterified Eicosanoids Are Generated in Agonist-activated Human Platelets and Enhance Tissue Factor-dependent Thrombin Generation.
Thomas CP et al, J Biol Chem -
Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells.
Hole PS et al, Blood -
Upregulating CD59: a new strategy for protection of neurons from complement-mediated degeneration.
Kolev MV et al, Pharmacogenomics J -
Sperm surface proteomics: from protein lists to biological function.
Brewis IA et al, Mol Hum Reprod -
Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation.
Tediose T et al, Nucleic Acids Res - More i3-IRG publications