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A randomized clinical trial to evaluate the effectiveness of a multimodal intervention in frail and prefrail older people with type 2 diabetes on frailty and quality of life

MID-Frail is a major new international research study examining the effectiveness of combining optimised medical

management with exercise and dietary programmes to maintain function and quality of life in people aged 70 years and over who have Type 2 diabetes.

Type 2 diabetes is a highly prevalent metabolic disorder in ageing populations, affecting approximately 20% of people aged 65 years and over. Diabetes is associated with increased frailty and an accelerated decline in the ability to carry out activities of daily living, which impairs quality of life.

There is a significant accompanying personal and social burden and increased healthcare costs through the effects of diabetes complications leading to increased hospitalisation rates.

Sixteen centres in seven countries across Europe will participate in this 4-year study, which is supported by the European Union. The project is co-ordinated by Professor Leocadio Rodríguez-Mañas (Hospital Universitario de Getafe, Madrid, Spain), an internationally-renowned geriatrician and Director of the Spanish Network on Ageing and Frailty (RETICEF) of the Ministry of Science and Innovation.

The Scientific Coordinator is Professor Alan Sinclair (University of Bedfordshire, UK). Professor Sinclair is an internationally-recognised expert in diabetes and old age medicine, Dean of the Beds & Herts Postgraduate Medical School and Director of the Institute of Diabetes for Older People (IDOP).


WP for data collection/management/analysis

Study Type

Randomised Control Trial (RCT)





Lead Investigator

T Bayer

Study Team

Professor Kerry Hood (Cardiff University)

CM Dayan

Study Status


Further Information

Dr Mark Kelson

Charlie Cowtan

Key data

Start date
Jan. 1, 2012
End date
Dec. 31, 2015
Grant value
General enquiries
Prof Kerry Hood

External links

Related pages