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EXERT-HD

Exercise Rehabilitation Trial in Huntington’s Disease

Huntington's disease (HD) is an inherited neurological disease, which over time results in progressive problems with movement, thinking and behaviour, and ultimately difficulties in undertaking usual activities of daily living. It is known that keeping physically active is important for any person who has a chronic health condition. Additionally, there is a growing interest in the potential that aerobic exercise may have for brain health, particularly for people with degenerative diseases such as HD. However, engaging in regular exercise can be difficult for people with HD given the complex and varied problems that they face on a daily basis.

This randomised study aims to evaluate the feasibility (in terms of adherence, process and safety) and benefit of a supported, structured exercise intervention in people with early to mid stage HD.

People with HD who enrol in the study will be asked to attend two research assessments (focussing on physical fitness, movement, thinking and walking abilities) over a three-month period at their local HD clinics. After the first assessment, they will be allocated to either the exercise intervention group or the control group. If they are assigned to the intervention, exercise trainers will work with each participant on an individualised exercise programme, either in their home or at a community gym. The intervention will take place three times per week for 12 weeks and trainers will supervise the participant in just over half the sessions. The remainder of the sessions will be conducted by the participant independently, or with support of a carer or family member.

SEWTU Role

PARTNERSHIP

Study Type

Exploratory Phase II multi-centre randomised control trial

Funder

Jacques and Gloria Gossweiler Foundation

Status

Open to recruitment

Themes

NISCHR - Neurodem and Primary Care

Chief Investigator:

Dr Lori Quinn

quinnL1@cardiff.ac.uk

School of Healthcare Sciences

Cardiff University

Ty Dewi Sant Heath Park

Cardiff CF14 4XN

Co-Investigators:

Dr Monica Busse

School of Healthcare Sciences

Cardiff University

Ty Dewi Sant, Heath Park

Cardiff CF14 4XN

busseme@cardiff.ac.uk

Professor Helen Dawes

Movement Science Group

School of Life Sciences

Oxford Brookes University

Gipsy Lane Campus, Headington

Oxford OX3 0BP

hdawes@brookes.ac.uk

Dr. Andrea Nemeth

Consultant and Honorary Senior Lecturer in Clinical Genetics

Clinical Genetics

Oxford Biomedical Research Centre (University of Oxford and Oxford Radcliffe NHS)

andrea.nemeth@eye.ox.ac.uk

Dr. Hugh Rickards

Hon. Reader in Neuropsychiatry

Department of Neuropsychiatry

The Barberry

25 Vincent Drive, Edgbaston

Birmingham B15 2FG

hugh.rickards@bsmhft.nhs.uk

Dr Ralf Reilmann

George-Huntington-Institute,Technology-Park - Deilmann Building IV, Johann-Krane-Weg 27, 48149 Münster, Germany

ralf.reilmann@ghi-muenster.de

Dr Raymund Roos

Dept Neurology, LUMC, Leiden, The Netherlands

0031 71 526 2197

r.a.c.roos@lumc.nl

Professor Anne Rosser

Cardiff Schools of Biosciences and Medicine, Cardiff University, Biomedical Building, Museum Avenue

Cardiff CF10 3US

rosserae@cardiff.ac.uk

Ms Julia Townson

7th Floor Neuadd Meirionnydd, SEWTU, Heath Campus, Cardiff University

02920 687606

townson@cardiff.ac.uk

Statistician:

Dr. Mark Kelson

Room 410, 4th Floor Neuadd Meirionnydd, SEWTU, Heath Campus, Cardiff University

KelsonMJ@cardiff.ac.uk

Trial co-ordinator

Ms. Katy Debono
Department of Physiotherapy, School of Healthcare Sciences
Ty Dewi Sant, Heath Park, Cardiff CF14 4XN

DebonoK1@Cardiff.ac.uk

Contact information

Email address
BusseME@Cardiff.ac.uk

Key data

Status
Running
Start date
Dec. 1, 2013
End date
Nov. 30, 2015
Grant value
£110, 170
General enquiries
Dr Monica Busse

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